Publications on Platform Development
2021:
- Junquan Lin, Wai HonChooi, WilliamOng, Na Zhang, Marie E.Bechler, Charles ffrench-Constant, Sing Yian Chew (2021), 'Oriented and sustained protein expression on biomimicking electrospun fibers for evaluating functionality of cells', Materials Science & Engineering C, 118, pp. 111407, https://doi.org/10.1016/j.msec.2020.111407
2020:
- Na Zhang, Junquan Lin, Jiah Shin Chin, Kunyu Zhang and Sing Yian Chew (2020), 'Laser microdissection-based axotomy model incorporating the use of biomimicking fiber scaffolds reveals microRNAs promote axon regeneration over long injury distance', Biomaterials Science, https://doi.org/10.1039/D0BM01380C
- Kunyu Zhang, Wai Hon Chooi, Shuang Liu, Jiah Shin Chin, Aoife Murray, Dean Nizetic, Du Cheng and Sing Yian Chew (2020), 'Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering', Biomaterials, 256, pp. 120225, https://doi.org/10.1016/j.biomaterials.2020.120225
2019:
- J Lin, I Mohamed, P H Lin, H Shirahama, U Milbreta, J L Sieow, Y Peng, M Bugiani, S C Wong, H Levinson, S Y Chew* (2019), ‘Modulating macrophage phenotype by sustained microRNA delivery improves host-implant integration’, Advanced Healthcare Materials, 9 (3), pp. 1901257, doi: 10.1002/adhm/201901257
- Junquan Lin, Dollaporn Anopas, Ulla Milbreta, Po Hen Lin, Jiah Shin Chin, Na Zhang, Seng Kwee Wee, Adela Tow, Wei Tech Ang, Sing Yian Chew (2019), 'Regenerative rehabilitation: Exploring the synergistic effects of rehabilitation and implantation of bio-functional scaffold in enhancing nerve regeneration', Biomaterials Science, 7, pp. 5150-5160, doi: 10.1039/C9BM01095E
- Jiah Shin Chin, Wai Hon Chooi, Hongxia Wang, William Ong, Kam W. Leong, Sing Yian Chew (2019), 'Scaffold-mediated non-viral delivery platform for CRISPR/Cas9-based genome editing', Acta Biomaterialia, 90, pp. 60-70, https://doi.org/10.1016/j.actbio.2019.04.020
- Na Zhang, U Milbreta, J S Chin, C Pinese, J Q Lin, H Shirahama, W Jiang, H Liu, R Mi, A Hoke, WT Wu, S Y Chew (2019), 'Biomimicking Fiber Scaffold as an Effective In Vitro and In Vivo MicroRNA Screening Platform for Directing Tissue Regeneration', Advanced Science, 6 (9), pp. 1800808, https://doi.org/10.1002/advs.201800808
2018:
- U Milbreta, J Q Lin, C Pinese, W Ong, J S Chin, H Shirahama, R Mi, A Williams, M E Bechler, J Wang, C french-Constant, A Hoke, S Y Chew (2019), 'Scaffold-mediated sustained, non-viral delivery of miR-219/miR-338 promotes CNS remyelination', Molecular Therapy, 27 (2), pp. 411-423, https://doi.org/10.1016/j.ymthe.2018.11.016
- W H Chooi, W Ong, A Murray, J Q Lin, D Nizetic, S Y Chew (2018), 'Scaffold mediated gene knockdown for neuronal differentiation of human neural progenitor cells', Biomaterials Science, 6, pp. 3019-3029, doi: 10.1039/C8BM01034J
- N Zhang, J S Chin, S Y Chew (2018), 'Localised non-viral delivery of nucleic acids for nerve regeneration in injured nervous systems', Experimental Neurology, 319, pp. 112820, https://doi.org/10.1016/j.expneurol.2018.09.003
- C Pinese, J Q Lin, U Milbreta, MQ Li, YC Wang, K W Leong, S Y Chew (2018), 'Sustained delivery of siRNA/mesoporous silica nanoparticle complexes from nanofiber scaffolds for long-term gene silencing', Acta Biomaterialia, 76, pp. 164-177, https://doi.org/10.1016/j.actbio.2018.05.054
- W Ong, J Q Lin, M E Bechler, K Wang, M F Wang, C fFrench-Constant, S Y Chew (2018), 'Microfiber Drug/Gene delivery Platform for Study of Myelination', Acta Biomaterialia, 75, pp. 152-160, https://doi.org/10.1016/j.actbio.2018.06.011
2017:
- L H Nguyen, M Y Gao, J Q Lin, W T Wu, J Wang and S Y Chew (2017), 'Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment', Scientific Reports, 7, Article number: 42212, doi: www.nature.com/articles/srep42212
2016:
- U Milbreta, L H Nguyen, H J Diao, J Q Lin, W T Wu, C-Y Sun, J Wang and S Y Chew (2016), 'Three-dimensional nanofiber hybrid scaffold directs and enhances axonal regeneration after spinal cord injury', ACS Biomaterials Science & Engineering, 2 (8), pp. 1319-1329, doi: 10.1021/acsbiomaterials.6b00248
2015:
- H J Diao, W C Low, R Q Lu, S Y Chew (2015), 'Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development', Biomaterials, 70, pp. 105-114, doi: 10.1016/j.biomaterials.2015.08.029
- S Y Chew (2015), 'MicroRNAs in tissue engineering and regenerative medicine', Advanced Drug Delivery Reviews, 88, pp. 1-2, doi: 10.1016/j.addr.2015.07.001
- W C Low, P-O Rujitanaroj, D K Lee, J Kuang, P B Messersmith, J K Y Chan, S Y Chew (2015), 'Mussel-inpsired modification of nanofibers for REST siRNA delivery: Understanding the effects of gene-silencing and substrate topography on human mesenchymal stem cell neuronal commitment', Macromolecular Bioscience, 15 (10), pp. 1457- 1468, doi: 10.1002/mabi.201500101
- L H Nguyen, H J Diao and S Y Chew (2015), 'microRNAs and their potential therapeutic applications in neural tissue engineering', Advanced Drug Delivery Reviews, 88, pp. 53-66, doi: 10.1016/j.addr.2015.05.007
- H J Diao, W C Low, U Milberta, Q R Lu and S Y Chew (2015), 'Nanofiber-mediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells', Journal of Controlled Release, 208, pp. 85-92 doi: 10.1016/j.jconrel.2015.03.005
- W C Low, P Rujitanaroj, F Wang, J Wang and S Y Chew (2015), 'Nanofiber-mediated release of retinoic acid and brain-derived neurotrophic factor for enhanced neuronal differentiation of neural progenitor cells', Drug Delivery and Translational Research, 5, pp. 89–10. doi: 10.10_07/s13346-013-0131-5.
- X Jiang, M H Nai, C T Lim, C Le Visage, J K Y Chan, S Y Chew (2015), 'Polysaccharide nanofibers with variable compliance for directingcell fate', Journal of Biomedical Materials Part A, 103 (3), pp. 959-968, doi: 10.1002/jbm.a.35237
2014:
- P Rujitanaroj, R Aid, S Y Chew* and C Le Visage (2014), 'Polysaccharide electrospun fibers with sulfated poly(fucose) promote endothelial cell migration and VEGF-mediated angiogenesis', Biomaterials Science, 2, pp. 843-852. (*Co-corresponding author). doi: 10.1039/C3BM60245A.
- X Jiang, R Mi, A Hoke, S Y Chew (2014), 'Nanofibrous nerve conduit-enhanced peripheral nerve regeneration', J Tissue Eng Regen Med., 8(5), pp. 377-385. doi: 10.1002/term.1531.
- S Rayatpisheh, D E Heath, A Shakouri, PO Rujitanaroj, S Y Chew, M B Chan-Park (2014), 'Combining cell sheet technology and electrospun scaffolding for engineered tubular, aligned, and contractile blood vessels', Biomaterials, 35(9), pp. 2713-2719. doi: 10.1016/j.biomaterials.2013.12.035.
2013:
- W C Low, P Rujitanaroj, D K Lee, P B Messersmith, L W Stanton, E Goh and S Y Chew (2013), 'Nanofibrous scaffold-mediated REST knockdown to enhance neuronal differentiation of stem cells', Biomaterials, 34 (14), pp. 3581-3590. doi:10.1016/j.biomaterials.2013.01.093.
- P Rujitanaroj, B Jao, J Yang, J Wang, J M Anderson and S Y Chew (2013), ‘Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) expression by nanofiber-mediated gene silencing’, Acta Biomaterialia, 9 (1), p. 4513-4524. doi: 10.1016/j.actbio.2012.09029.
2012:
- Y Liu, S Rayatpisheh, S Y Chew, M B Chan-Park (2012), 'Impact of endothelial cells on 3D cultured smooth muscle cells in a biomimetic hydrogel', ACS Appl Mater Interfaces, 4(3), pp. 1378-87. doi: 10.1021/am201648f.
- L Shi, R Aid, C Le Visage, S Y Chew (2012), 'Biomimicking polysaccharide nanofibers promote vascular phenotypes: a potential application for vascular tissue engineering', Macromol Biosci., 12(3), pp. 395-401. doi: 10.1002/mabi.201100336.
- T Liu, J D Houle, J Xu, B P Chan, S Y Chew (2012), 'Nanofibrous collagen nerve conduits for spinal cord repair', Tissue Eng Part A., 18(9-10), pp. 1057-66. doi: 10.1089/ten.TEA.2011.0430.
- X Jiang, H Q Cao, L Y Shi, S Y Ng, L W Stanton, S Y Chew (2012), 'Nanofiber topography and sustained biochemical signaling enhance human mesenchymal stem cell neural commitment', Acta Biomater., 8 (3), pp. 1290-302. doi: 10.1016/j.actbio.2011.11.019.
- T Liu, J Xu, B P Chan, S Y Chew (2012), 'Sustained release of neurotrophin-3 and chondroitinase ABC from electrospun collagen nanofiber scaffold for spinal cord injury repair', J Biomed Mater Res A. 100 (1), pp. 236-42. doi: 10.1002/jbm.a.33271.
2011:
- P O Rujitanaroj, Y C Wang, J Wang J, S Y Chew (2011), 'Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications', Biomaterials, 32(25), pp. 5915-5923. doi: 10.1016/j.biomaterials.2011.04.065.
- Handarmin, G J Y Tan, S Bibekananda, G T Marcy, E L K Goh and S Y Chew (2011), 'Nanofibrous scaffold with incorporated protein gradient for directing neurite outgrowth', Drug Delivery and Translational Research, 1(2), pp. 147-160, https://link.springer.com/article/10.1007/s13346-011-0017-3.
- L Shi, C Le Visage, S Y Chew (2011), 'Long-term stabilization of polysaccharide electrospun fibres by in situ cross-linking', J Biomater Sci Polym Ed., 22 (11), pp.1459-1472. doi: 10.1163/092050610X512108.
2010:
- T Liu, W K Teng, B P Chan and S Y Chew (2010), 'Photochemical Crosslinked Electrospun Collagen Nanofibers: Synthesis, Characterization & Neural Stem Cell Interactions', Journal of Biomedical Materials Research: Part A, 95(1), pp. 276-282. doi: 10.1002/jbm.a.32831.
- H Q Cao, X Jiang, C Chai, S Y Chew (2010), 'RNA interference by nanofiber-based siRNA delivery system', J Control Release, 144 (2), pp. 203-212. doi: 10.1016/j.jconrel.2010.02.003.
- X Jiang, S H Lim, H Q Mao, S Y Chew (2010), 'Current applications and future perspectives of artificial nerve conduits',Current applications and future perspectives of artificial nerve conduits', Exp Neurol., 223 (1), pp. 86-101. doi: 10.1016/j.expneurol.2009.09.009.
2009 & before:
- H Q Cao, L Ting and S Y Chew (2009), 'The Application of Nanofibrous Scaffolds in Neural Tissue Engineering', Advanced Drug Delivery Reviews, 61 (12), pp. 1055-1064. doi: 10.1016/j.addr.2009.07.009.
- S Y Chew, T G Park (2009), 'Nanofibers in regenerative medicine and drug delivery', Adv Drug Deliv Rev., 61(12), pp. 987. doi: 10.1016/j.addr.2009.07.004. (Preface by Theme Editors).
- S Y Chew , R Mi, A Hoke and K W Leong (2007), ‘Aligned protein-polymer composite fibers enhance nerve regeneration – A potential tissue engineering platform’, Advanced Functional Materials, 17, pp. 1288-1296, 2007. doi: 10.1002/adfm.200600441. Download.
- I C Liao, S Y Chew and K W Leong (2006), “Aligned core-shell nanofibers delivering bioactive proteins’, Nanomedicine, 1(4), pp. 465-471. doi: 10.2217/17435889.1.4.465. Download.
- S Y Chew , T C Hufnagel, C T Lim and K W Leong (2006), ‘Mechanical properties of single electrospun drug-encapsulated nanofibers’, Nanotechnology, 17 (15), pp. 3880-3891. doi: 10.1088/0957-4484/17/15/045.
- S Y Chew , Y Wen, Y Dzenis and K W Leong (2006), ‘The role of electrospinning in the emerging field of nanomedicine’, Current Pharmaceutical Design, 12, pp. 4751-4770. doi: 10.2174/138161206779026326. Download.
- S Y Chew , J Wen, E K F Yim and K W Leong (2005), ‘Sustained release of proteins from electrospun biodegradable fibers’, Biomacromolecules, 6(4): 2017-2024. doi: 10.1021/bm0501149.